HUANG LAB

Bringing New Catalytic Functions to Metalloenzymes

We harness the power of directed evolution to solve outstanding problems at the frontiers of chemistry and biology

Research Highlights

Science_2022

Directed evolution of nonheme iron enzymes to access abiological radical-relay C−H azidation

Rui et al. Science 2022, 376, 869–874.

2024_Nat_Catal

Merging photoredox with metalloenzymatic catalysis for enantioselective decarboxylative C‒N₃ and C‒SCN bond formation

Rui et al. Nat. Catal. 2024, 7, 1394–1403

2024_Nat_Synth

Engineering non-haem iron enzymes for enantioselective C–F bond formation via radical fluorine transfer

Zhao and Chen et al. Nat. Synth. 2024, 3, 958–966.

JACS

Biocatalytic generation of trifluoromethyl radicals by nonheme iron enzymes for enantioselective alkene difunctionalization

Zhang and Huls et al. J. Am. Chem. Soc. 2024, 146, 34878–34886

Xiongyi Huang, Ph.D.
Assistant Professor
Department of Chemistry

Office Location: 155 Remsen Hall
Johns Hopkins University
3400 North Charles St, Baltimore, MD 21218