Bringing New Catalytic Functions to Metalloenzymes

We harness the power of directed evolution to solve outstanding problems at the frontiers of chemistry and biology

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Recent News and Publications

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Directed evolution of nonheme iron enzymes to access abiological radical-relay C−H azidation

Rui et al. Science, 2022, 376, 869–874.

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Engineering non-haem iron enzymes for enantioselective C–F bond formation via radical fluorine transfer

Zhao and Chen et al. Nat. Synth., 2024, 3, 958–966.

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Biocatalytic generation of trifluoromethyl radicals by nonheme iron enzymes for enantioselective alkene difunctionalization

Zhang and Huls et al. ChemRxiv., 2024

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Contact

Xiongyi Huang, Ph.D.
Assistant Professor
Department of Chemistry

Office Location: 155 Remsen Hall
Johns Hopkins University
3400 North Charles St, Baltimore, MD 21218

  • xiongyi@jhu.edu
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